Tuesday, September 26, 2017

HIV rates climbing among over-50s in UK and Europe, researchers warn

Older people more likely to be infected through heterosexual sex and to have more advanced disease when it is finally diagnosed, new study reveals
The National Aids Trust say say that action is needed to prevent infection, such as offering HIV tests in places other than sexual health clinics.
The National Aids Trust say say that action is needed to prevent infection, such as offering HIV tests in places other than sexual health clinics. Photograph: Chip Somodevilla/Getty Images
HIV rates are climbing in the over-50s in the UK and across Europe, while the rate of new infections among younger people is dropping, according to new research which warns that the epidemic may be taking a new direction.
The study, from the European Centre for Disease Prevention and Control in Sweden, says that older people are most likely to be infected through heterosexual sex. They are also likely to have more advanced disease – which will be harder to treat and could be life-threatening – when it is finally picked up.
The study’s authors suggest that the over-50s may be either complacent or ignorant of the risks of HIV, which has dropped out of the headlines since it became a treatable disease. Their doctors also tend to assume that older people are not running risks through unsafe sex.
“Our findings suggest a new direction in which the HIV epidemic is evolving,” said lead author Dr Lara Tavoschi. “This potentially is a result of older peoples’ low awareness of HIV and how it is transmitted, leading to misconceptions and low perception of their own risk.
“This perception of older people not being at risk is shared by some healthcare providers, and HIV-related services focus more on younger people. Our study shows the need to ensure all ages are appropriately targeted by sexual health services.”
The study, published in the Lancet HIV journal, has found that one in six new cases of HIV are in people over the age of 50. Between 2004-2015, the rate of diagnosis in older people increased in 16 countries. That included the UK, where the rate of new diagnoses went up from 3.1 per 100,000 to 4.32. Belgium, Germany and Ireland also saw rises in the rate of infection among older people. By 2015, the rate in over-50s was highest in Estonia, Latvia, Malta, and Portugal.
While the rate of newly reported cases remained steady in those aged 15 to 49, it grew by 2.1% each year overall in older people across the 28 European nations, increasing from 2.1 people in every 100,000 in 2004 to 2.5 per 100,000 in 2015.
Infection through sex between men increased in both age groups between 2004-2015. Cases due to heterosexual sex reduced in younger people and remained stable in older people, while those attributable to injecting drug use also reduced in younger people but increased in older people.
The National Aids Trust said they had been aware of the rising rates in older people in the UK for some time and that action was needed to prevent these infections, such as targeting different age groups – not just the young – with information about their risks and offering HIV tests in places other than sexual health clinics, such as GP surgeries.
“In recent years there has been a steady increase in HIV diagnoses amongst people over the age of 50 in the UK, accounting for 9% of new diagnoses in 2006 and 17% in 2015,” said Kat Smithson, director of policy and campaigns. “The trend is not limited to, but is more prominent, in the heterosexual population. This presents a challenge to think about whether our prevention efforts meet the needs of changing demographics.”
Government cuts to public health budgets were damaging local authorities’ capacity to offer prevention and testing to older people,” she said. “High prevalence areas are spending a third less on HIV prevention than they were two years ago, and it’s targeted services that are suffering most. We are concerned that generalised health promotion around sexual health and HIV may not reach some smaller but growing areas of need, such as in the older heterosexual population. We have the tools to reverse this trend, but without investment we cannot use them.”
Professor Janet Seeley from the London School of Hygiene and Tropical Medicine, who wrote a commentary in the Lancet on the study, said that many older people did not think they were running a risk. “The main thing is complacency, and also they are in relationships where pregnancy is not a problem, so contraception isn’t something people consider,” she said. “I think there is very little publicity around HIV in Europe now that prevalence and incidence have gone down.”
The new infections were more often caused by heterosexual sex, she thought, because the gay community was far more aware of the risks. “Men of that particular age have gone through quite a lot themselves,” she said. It would be naive to expect governments to do anything about increasing awareness among the over-50s, given the pressures on health services, she acknowledged, but the study should encourage big campaigning groups – in particular the Terrence Higgins Trust, which had been working on the issue. “It is a very difficult group to reach,” she said. “It is very heterogeneous. If someone is going for a well-man or well-woman check up, it could be something the GP could mention.” It is difficult to ask people if they are having unprotected sex in a new relationship, but few people took notice of leaflets because they didn’t think they were relevant to them, she added.
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Tavoschi says that HIV services need to be geared up to the needs of this age group. “Our findings illustrate a clear need to provide comprehensive HIV prevention programmes, including education, access to condoms, better testing opportunities, and treatment, targeted towards older adults across Europe,” she said.
“We need to make both healthcare workers and the general population aware of this issue to reduce stigma and inform people about HIV risks and prevention methods. Testing in healthcare settings and innovative HIV test approaches – such as self-testing – need to be more easily accessible to older people to improve early diagnosis and fast-track treatment initiation. When achieved, this should help to prevent further transmission and lower the risk of severe health complications, which is of utmost importance among older adults living with HIV as their risk of mortality is higher as compared to younger individuals.”

New vaccine by Pune-based institute safe against severe rotavirus gastroenteritis: Study

To be launched in Nov; Centre orders 3.8 million doses for use in Universal Immunisation Programme

 diarrhoea, diarrhoea vaccine, rotavirus gastroenteritis, rotavirus gastroenteritis vaccine, Serum Institute of India, ROTASIL vaccine, 
The results showed that ROTASIL reduced severe rotavirus diarrhoea by more than a third, by 39.5 per cent over two years.
A new vaccine against rotavirus gastroenteritis, developed by the Pune-based Serum Institute of India, promises to be a cost-effective and heat-stable option in the global strategy for diarrhoea prevention, according to the results of a study published in the international journal Vaccine.
Rotavirus is the most common cause of diarrhoea and one of the leading causes of mortality among children who are under five years of age. Rotavirus accounts for approximately 40 per cent of all diarrhoea cases requiring treatment. A Rotavirus disease cannot be treated with antibiotics or other drugs.
The new vaccine, ROTASIL, is supposed to be orally administered to infants in a three-dose course at 6, 10, and 14 weeks of age, at the same time when the existing vaccinations under India’s Universal Immunisation Programme are administered.
The international non-profit PATH partnered with Serum Institute to evaluate this vaccine in the Phase 3 efficacy study. Initiated in May 2014, the study was conducted at clinical sites across six places in India — Pune, Kolkata, Sewagram, Delhi, Manipal, and Jammu. A total of 7,500 infants were followed from the time of vaccination until 2 years of age, to check the efficacy and safety outcomes.

The results showed that ROTASIL reduced severe rotavirus diarrhoea by more than a third, by 39.5 per cent over two years. The vaccine efficacy was nearly 55 per cent against the most severe and potentially life-threatening cases of rotavirus diarrhoea, which represent the highest risk of dehydration, hospitalisations, and deaths.
“The Centre has placed an order for 3.8 million doses of the vaccine to use in the Universal Immunisation Programme, which serves 26 million children. The Serum Institute has manufactured the vaccine doses and will launch the vaccine in November,” Dr Rajeev Dhere, executive director of the Serum Institute of India, told The Indian Express.
It is estimated that 11.37 million episodes of rotavirus gastroenteritis occur every year in India alone, and they require 3.27 million outpatient visits and 872,000 in-patient admissions. In 2013, an estimated 47,100 rotavirus deaths occurred in India — 22 per cent of all rotavirus deaths that occurred globally. Currently, two rotavirus vaccines — Rotarix and RotaTeq — are licensed internationally and are prequalified by the World Health Organisation. A third vaccine, Rotavac, was recently licensed in India.
Despite the presence of these vaccines, there remains an overwhelming need for cost-effective and safe rotavirus vaccines for the worst-affected countries, said Dr Prasad Kulkarni, medical director at Serum Institute of India, who led the study.
Meanwhile, Médecins Sans Frontieres and Epicentre are also evaluating the efficacy and safety of ROTASIL in a separate Phase 3 study in Niger.  That study is still ongoing, but results from the primary analysis also showed the vaccine to be highly efficient for the prevention of severe rotavirus diarrhoea, and with an excellent safety profile. The efficacy of the vaccine against severe and very severe rotavirus diarrhoea in the Niger study was 66.7 per cent and 78.8 per cent, respectively. These results were published in the New England Journal of Medicine in March 2017.

From Monday, pregnant women, new moms to get hot meals

By Express News Service  |   Published: 27th September 2017 03:23 AM  |  
Last Updated: 27th September 2017 07:28 AM  |   A+A-   |  
BENGALURU: A maternal nutrition scheme, ‘Mathrupoorna’, which will provide one freshly cooked meal to pregnant and lactating mothers, will be launched on October 2. The scheme will replace the take-home meals that were being offered as part of the supplementary nutrition programme under the Integrated Child Development Scheme (ICDS).
Under this programme, pregnant and breastfeeding mothers will be given one full meal during the day consisting of rice, dal, lentils, vegetables, boiled egg, peanut (chikki) and milk for a minimum of 25 days every month. The women will also be given iron, folic acid and calcium tablets along with the meal. The one meal will be of 1,342 calories and will meet up to 45 per cent of the recommended daily nutritional need. The meal will be served at local anganwadis. Similar schemes are already being implemented in Telangana, Andhra Pradesh and Maharashtra.
A pilot project was conducted in February at Manvi, H D Kote, Jamkhandi and Madhugiri taluks, where 36,000 women were covered under the scheme. The scheme is expected to benefit 12 lakh women in the state. Since the meals will be cooked at anganwadis, the Department of Women and Child Development (DWCD) has decided that meals served to children (3-6 years) will also be the same so that meals do not have to cooked twice.
Keeping in mind the restrictions placed on new mothers, meals will be allowed to be taken home 30 days before delivery and 45 days after. In coastal areas like Uttara Kannada and Udupi, where anganwadis are far away, DWCD is considering allowing women to take the meals home.
Principal Secretary to DWCD Uma Mahadevan said surveys held in the past decade had shown that malnutrition, stunted growth and wasting has not reduced much in children who do not have access to better facilities. “We realised that to address the issue, it is not sufficient to focus on the child alone, but also on the mother.  Most of the women are anaemic and calcium deficient before pregnancy and this contributes to poor health of the child and in the long term, poorer prospects of leading a better life,” she said.
While the DWCD will focus on providing the meal, the Health and Family Welfare Department, through ASHA workers and Auxiliary Nurse Midwives, will record their development through mother and child tracking software, check haemoglobin content and also counsel on birth preparedness.
Several issues to cover
The successful implementation of the scheme which follows a life-cycle approach, with focus on the mother and the child too stands a better chance, depending on how DWCD manages several problems. There is some resistance among anganwadi workers who feel they are not able to concentrate on their core function as they are being frequently drawn into other works like surveys and census. While stress is also being laied on construction of toilets to prevent diarrhoea and other infections, encouraging women and children to use the toilets when water is a scarce commodity in north Karnataka is also a challenge. In addition, the DWCD also has been unable to tackle child marriages satisfactorily, despite conducting awareness campaigns.  Also, younger anaemic mothers have a higher rate of maternal mortality and also give birth to underweight children. Whether families are willing to let these young mothers have access to these meals is yet to be seen.