Saturday, April 18, 2020

FDA Urges Recovered COVID-19 Patients to Donate Plasma

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Kerala to Allow Restaurant Dining Till 7pm, Odd-Even Scheme in Non-Hotspots After Flattening Curve


News18 » India
3-min read

Kerala to Allow Restaurant Dining Till 7pm, Odd-Even Scheme in Non-Hotspots After Flattening Curve

The districts in the red zone - Kasaragod, Kannur, Kozhikode, Malappuram - will not have any relaxations, the guidelines said, and hotspots in each of them will remain sealed.

Neethu Reghukumar | CNN-News18
Updated:April 18, 2020, 2:01 PM IST
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Kerala to Allow Restaurant Dining Till 7pm, Odd-Even Scheme in Non-Hotspots After Flattening Curve
Kerala has greatly managed to flatten the curve as fresh daily cases have dropped to the single-digit level. (PTI photo)
Thiruvananthapuram: The Pinarayi Vijayan government on Saturday released detailed guidelines to reopen Kerala in a staggered manner from Monday as it divided the state into four zones – Red, Orange A, Orange B and Green.
The districts in the red zone - Kasaragod, Kannur, Kozhikode, Malappuram - will not have any relaxations, the guidelines said, and hotspots in each of them will remain sealed and have only two entry/exit points for supply of essential goods and services.
In other places based on the zone classification, private vehicles will be allowed in odd-even scheme within the districts, and even restaurants will be allowed dine-in facilities till 7 pm and takeout till 8 pm. Bus travel for short distances will also be allowed within districts. Strict social distancing norms will have to be followed for all these services, officials said.
In Pathanamthitta, Ernakulam and Kollam, districts under Orange A zone, partial relaxation from the lockdown will be given from April 24, while Orange B districts Alappuzha, Trivandrum, Palakkad, Wayanad and Thrissur will get partial relaxation from Monday.
The state has greatly managed to flatten the curve as fresh daily cases have dropped to the single-digit level and number of people getting discharged from hospitals greatly outnumbering new admissions. In the last 7 days, there have been just 32 new cases, while 129 Covid-19 patients have been discharged in the same time period.
The government has classified two districts, Kottayam and ldukki, in the green zone, that will greatly see restrictions being lifted from Monday.
Here’s a lowdown of what will be allowed in Orange Zone districts:
- Movement of private vehicles with odd-even scheme. Vehicles with odd numbers will be permitted on Mondays, Wednesdays and Fridays, while vehicles with even numbers will be allowed on Tuesdays, Thursdays and Saturdays.
- The exemption from the odd-even scheme would be only for critical services and emergency operations. Women traveling solo or with dependents are exempted from this restriction.
- Only two passengers besides the private vehicle driver can be permitted in the backseat in case of four-wheelers and only one person allowed on two-wheelers. A pillion rider is allowed if it’s a family member.
- Bus travel for short distances permitted subject to a strict discipline: no standing passengers, wearing masks compulsory and hand sanitizers should be provided to the passengers as they enter the buses. Total distance cannot more be than 50 to 60 km, limited to within the district.
- Barber shops (no cosmetics/beauty therapies) allowed to open on Saturday and Sunday but without AC. Only 2 people to wait at a time.
- Restaurants allowed to have dine-in services till 7 pm and takeout till 8 pm.
- All health services to remain functional.
- Authorized private establishments, which support the provisioning of essential services, or efforts for containment of COVID-19, including home care providers, diagnostics, and supply chain firms serving hospitals to remain functional.
- Pre-monsoon sanitation and preventive activities by Health department and local bodies allowed.
- All agricultural and horticultural activities including farming operations by farmers, ngencies engaged in procurement, marketing and sale of agriculture/horticulture/horticulture products permitted.
- Operation of Anganwadis - distribution of food and nutritional items once in 15 days at the doorsteps of beneficiaries.
- MGNREGA and Ayyankali Employment Guarantee Scheme works to be allowed with strict implementation of social distancing and face masks. Priority to be given to irrigation and water conservation works. Not more than 5 unskilled labourers in a team.
- Operations of utilities in water, sanitation and waste management sectors including garbage collection by locaI bodies or agencies authorized by Government for that purpose.
- Construction of roads, irrigation projects, buildings and all kinds of industrial projects, including MSMEs in rural areas will be allowed.
-No person with symptoms like fever, cough, shall be engaged to work. Heath check-up of migrant workers will be the responsibility of the contractor or employer.
In Green category districts, all activities, except the following will be permitted after April 20:
- No domestic and international air travel of passengers.
- No passenger movement by trains.
- Inter-district public transport of all kinds to remain banned.
- Metro rail services will remain closed.
- All educational, training, coaching institutions will remain closed.
- All cinema halls, malls, shopping complexes, gymnasiums, sports complexes, swimming pools, entertainment parks, theatres, bars and auditoriums, assembly halls will remain closed.
- All social, political, sports, entertainment, academic, cultural, religious functions and other gatherings are banned.
- All religious places shall be closed for public. Religious congregations are strictly prohibited.
- In case of funerals and marriages, congregation of more than twenty persons will not be permitted.

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Wednesday, April 15, 2020

The Impact of Egg Nutrient Composition and Its Consumption ... https://www.ncbi.nlm.nih.gov ›

by H Kuang - ‎2018 - ‎Cited by 14 - ‎Related articles
Aug 23, 2018 - Daily intake of eggs and egg products in US children and adults accounts for ... The nutrients to energy density ratio of one egg i

6.3. Effect of Egg Intake on Blood Cholesterol and CVD in Human Studies

The effects of egg intake on blood cholesterol and CVD have been discussed in several meta-analysis studies using research data collected over 60 years [, , , ]. Large epidemiological works have been conducted to investigate the effect of egg intake on blood cholesterol levels and risk of CVD in children [], young people [, , , ], women [, , , ], men [, , ], and older adults [, , ]. Some have shown that egg consumption did influence the blood cholesterol level but did not increase the risk of CVD in healthy people. Meanwhile, other studies reported that high dietary cholesterol intake due to egg consumption is a risk factor for CVD and diabetes [, , , , ]. The results of epidemiological studies and human intervention studies on the relationship of dietary egg intake and CVD risks are summarized in Table 3. Even though AHA and DGAC have removed the restriction of dietary cholesterol for healthy people in USA, there still are different conclusions due to differences in race, genetic makeup, physical fitness, and especially physiological status.
Among the 19 prospective studies investigating the effect of dietary egg intake on CVD risks, 6 studies reported positive correlation between egg consumption and different types of CVD incidents or mortality in healthy people [, , , , , ]. Pang (2017) reported the positive correlation with total cholesterol [], and Spence (2012) reported the positive correlation with plaque area []. However, other studies (11 out of 19) reported no difference on the CVD risks affected by the amount of egg intake. The adverse effect of egg consumption is observed in population with high risk of CVD, including people with diabetes or hypercholesterolemia, and who are sensitive to dietary cholesterol [, , , , , ]. Diabetic populations are in the high risk of CVD with two to four folds higher than healthy people. These studies also showed that diabetic people are more vulnerable to CVD after egg consumption [, ], with a doubling of coronary risk with an egg per day in US population [, ], and 5-fold risk in Greece population []. Meanwhile, some studies found that high egg consumption increased the risk of gestational diabetes mellitus [], insulin resistance [], and the risk of diabetes []. Therefore, the effect of egg consumption on CVD might be mediated by diabetes.
Almost all human intervention studies showed the serum LDL and HDL cholesterol levels increased in high egg consuming groups (1 to 3 eggs per day comparing to no egg or with egg substitute), while the ratio of serum LDL to HDL (LDL/HDL) is unchanged (Table 3). Most of these papers concluded that egg consumption is not a risk factor for CVD, based on the fact that the LDL/HDL ratio is unchanged because this ratio is thought to be a stronger risk factor for CVD. However, serum LDL level alone should still be considered as a risk factor for CVD. This is especially true for those people whose blood cholesterol level is more sensitive to dietary cholesterol consumption. There are good reasons for the recommendation that persons at risk of vascular disease limit cholesterol to 200 mg/day []. The very high cholesterol content of egg yolk (237 mg in a 65-gram egg) is a problem in itself, and even one large egg yolk exceeds that limit. Other studies reported the high cholesterol and high lipid diet could induce the inflammation in plasma, which is thought to contribute to atherosclerosis [], and the susceptibility of LDL to be oxidized could be increased by dietary cholesterol [].

7. Outlook

Interestingly, current studies have tended to show that the consumption of eggs is not a risk factor of CVD in healthy people. However, people who are at high risk of CVD such as those with diabetes or hypertension need to have caution with dietary cholesterol intake, especially egg intake. Also, some people seem to be more sensitive to dietary cholesterol whose blood cholesterol level is highly correlated to dietary intake. Therefore, even though the recommendation of restricting cholesterol and egg consumption in AHA and DGAC has been eliminated, we still need to have caution with them based on the physiological status of people. On the other hand, the studies on the egg components impacting CVD risk showed that some egg components have potential protective effects on CVD, while others may have adverse effects. Due to the lack of complete data, the components of eggs that regulate cholesterol absorption and metabolism have not been extensively studied systematically. To solve the mystery of the relationship between egg cholesterol and blood cholesterol, it is essential to understand intestinal absorption of cholesterol from eggs and study the effect of cholesterol in eggs, and nutrients and cholesterol interactions in eggs. Also, the function of gut microbiota needs to be taken into consideration as well. Overall, in order to strengthen the basic research of egg functional components, understanding of the nutritional value of eggs can provide theoretical data for reasonable determination of the intake of eggs.

Acknowledgments

Funding for open access to this article was provided by University of Tennessee's Open Publishing Support Fund.

Conflicts of Interest

All authors declared no conflicts of interest.

References

1. Wang H., Naghavi M., Allen C., et al. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 2016;388(10053):1459–1544.19802015 [PMC free article] [PubMed] []
2. Ostör E., Jánosi A., Adám Z., et al. Secondary prevention of coronary disease—t the turn of the millennium in light of the Hungarian data of the EUROASPIRE I-II. Studies. Orvosi Hetilap. 2003;144(49):2399–2404. [PubMed] []
3. Dawber T. R., Moore F. E., Mann G. V. II. Coronary heart disease in the Framingham study. International Journal of Epidemiology. 2015;44(6):1767–1780. doi: 10.1093/ije/dyv346. [PubMed] [CrossRef] []
4. Mann G. V., Pearson G., Gordon T., Dawber T. R., Lyell L., Shurtleff D. Diet and cardiovascular disease in the Framingham study. 1. Measurement of dietary intake. Journal of Clinical Nutrition. 1962;11:200–225. doi: 10.1093/ajcn/11.3.200. [PubMed] [CrossRef] []
5. Anitschkow N. On experimental cholesterin steatosis and its significance in the origin of some pathological processes. Zentralblatt der Allegemeine Pathologie und Anatomie. 1913;24:p. 1. []
6. Shekelle R., Stamler J. Dietary cholesterol and ischaemic heart disease. The Lancet. 1989;333(8648):1177–1179. doi: 10.1016/S0140-6736(89)92759-1. [PubMed] [CrossRef] []
7. Kushi L. H., Lew R. A., Stare F. J., et al. Diet and 20-Year Mortality from Coronary Heart Disease: The Ireland–Boston Diet–Heart Study. The New England Journal of Medicine. 1985;312(13):811–818. doi: 10.1056/NEJM198503283121302. [PubMed] [CrossRef] []
8. American Heart Association. The National Diet-Heart Study. American Heart Association; 1968. []
9. United States Department of Agriculture: Agricultural Research Service. Nutrient Intakes from Food and Beverages:Mean Amounts Consumed Per Individual, by Gender and Age, What We Eat in America. NHANES 2013-2014. https://www.ars.usda.gov/ba/bhnrc/fsrg.
10. Keast D. R., Fulgoni V. L., III, Nicklas T. A., O'Neil C. E. Food sources of energy and nutrients among children in the United States: National Health and Nutrition Examination Survey 2003-2006. Nutrients. 2013;5(1):283–301. doi: 10.3390/nu5010283. [PMC free article] [PubMed] [CrossRef] []
11. O'Neil C. E., Keast D. R., Fulgoni V. L., III, Nicklas T. A. Food sources of energy and nutrients among adults in the US: NHANES 2003-2006. Nutrients. 2012;4(12):2097–2120. doi: 10.3390/nu4122097. [PMC free article] [PubMed] [CrossRef] []
12. Hu F. B., Stampfer M. J., Rimm E. B., et al. A prospective study of egg consumption and risk of cardiovascular disease in men and women. Journal of the American Medical Association. 1999;281(15):1387–1394. doi: 10.1001/jama.281.15.1387. [PubMed] [CrossRef] []
13. Qureshi A. I., Suri M. F. K., Ahmed S., Nasar A., Divani A. A., Kirmani J. F. Regular egg consumption does not increase the risk of stroke and cardiovascular diseases. Medical Science Monitor. 2007;13(1):CR1–CR8. [PubMed] []
14. Nakamura Y., Iso H., Kita Y., et al. Egg consumption, serum total cholesterol concentrations and coronary heart disease incidence: Japan Public Health Center-based prospective study. British Journal of Nutrition. 2006;96(5):921–928. [PubMed] []
15. Rong Y., Chen L., Zhu T., et al. Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies. British Medical Journal. 2013;346 doi: 10.1136/bmj.e8539.e8539 [PMC free article] [PubMed] [CrossRef] []
16. Rueda J. M., Khosla P. Impact of breakfasts (with or without eggs) on body weight regulation and blood lipids in university students over a 14-week semester. Nutrients. 2013;5(12):5097–5113. doi: 10.3390/nu5125097. [PMC free article] [PubMed] [CrossRef] []
17. Virtanen J. K., Mursu J., Virtanen H. E. K., et al. Associations of egg and cholesterol intakes with carotid intima-media thickness and risk of incident coronary artery disease according to apolipoprotein e phenotype in men: The Kuopio Ischaemic Heart Disease Risk Factor Study. American Journal of Clinical Nutrition. 2016;103(3):895–901. doi: 10.3945/ajcn.115.122317. [PubMed] [CrossRef] []
18. DiMarco D. M., Norris G. H., Millar C. L., Blesso C. N., Fernandez M. L. Intake of up to 3 Eggs per Day Is Associated with Changes in HDL Function and Increased Plasma Antioxidants in Healthy, Young Adults. Journal of Nutrition. 2017;147(3):323–329. doi: 10.3945/jn.116.241877. [PubMed] [CrossRef] []
19. Missimer A., Fernandez M. L., DiMarco D. M., et al. Compared to an Oatmeal Breakfast, Two Eggs/Day Increased Plasma Carotenoids and Choline without Increasing Trimethyl Amine N-Oxide Concentrations. Journal of the American College of Nutrition. 2018;37(2):140–148. doi: 10.1080/07315724.2017.1365026. [PubMed] [CrossRef] []
20. Lemos B. S., Medina-Vera I., Blesso C. N., Fernandez M. L. Intake of 3 eggs per day when compared to a choline bitartrate supplement, downregulates cholesterol synthesis without changing the LDL/HDL ratio. Nutrients. 2018;10(2) [PMC free article] [PubMed] []
21. Shin J. Y., Xun P., Nakamura Y., He K. Egg consumption in relation to risk of cardiovascular disease and diabetes: a systematic review and meta-analysis. American Journal of Clinical Nutrition. 2013;98(1):146–159. [PMC free article] [PubMed] []
22. Tran N. L., Barraj L. M., Heilman J. M., Scrafford C. G. Egg consumption and cardiovascular disease among diabetic individuals: A systematic review of the literature. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2014;7:121–137. [PMC free article] [PubMed] []
23. Alexander D. D., Miller P. E., Vargas A. J., Weed D. L., Cohen S. S. Meta-analysis of Egg Consumption and Risk of Coronary Heart Disease and Stroke. Journal of the American College of Nutrition. 2016;35(8):704–716. doi: 10.1080/07315724.2016.1152928. [PubMed] [CrossRef] []
24. Eckel R. H., Jakicic J. M., Ard J. D., et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American college of cardiology/American heart association task force on practice guidelines. Journal of the American College of Cardiology. 2014;63(25, part B):2960–2984. doi: 10.1016/j.jacc.2013.11.003. [PubMed] [CrossRef] []
25. USDA National Nutrient Database for Standard Reference. Beltsville, MD, USA: US Department of Agriculture, Agricultural Research Service, Nutrient Data Laboratory; 2015. []
26. Miranda J. M., Anton X., Redondo-Valbuena C., et al. Egg and egg-derived foods: effects on human health and use as functional foods. Nutrients. 2015;7(1):706–729. doi: 10.3390/nu7010706. [PMC free article] [PubMed] [CrossRef] []
27. USDA: United States Department of Agriculture. Choice Reviews Online. 2011;48(07):48-3859–48-3859. doi: 10.5860/CHOICE.48-3859. [CrossRef] []
28. Rakonjac S., Bogosavljević-Bošković S., Pavlovski Z., et al. Laying hen rearing systems: A review of major production results and egg quality traits. World's Poultry Science Journal. 2014;70(1):93–104. doi: 10.1017/S0043933914000087. [CrossRef] []
29. Jung S., Kim D. H., Son J. H., Nam K., Ahn D. U., Jo C. The functional property of egg yolk phosvitin as a melanogenesis inhibitor. Food Chemistry. 2012;135(3):993–998. doi: 10.1016/j.foodchem.2012.05.113. [PubMed] [CrossRef] []
30. Natoli S., Markovic T., Lim D., Noakes M., Kostner K. Unscrambling the research: Eggs, serum cholesterol and coronary heart disease. Nutrition & Dietetics. 2007;64(2):105–111. doi: 10.1111/j.1747-0080.2007.00093.x. [CrossRef] []
31. Villaume C., Beck B., Rohr R., Pointel J. P., Debry G. Effect of exchange of ham for boiled egg on plasma glucose and insulin responses to breakfast in normal subjects. Diabetes Care. 1986;9(1):46–49. doi: 10.2337/diacare.9.1.46. [PubMed] [CrossRef] []
32. Pelletier X., Thouvenot P., Belbraouet S., et al. Effect of egg consumption in healthy volunteers: Influence of yolk, white or whole-egg on gastric emptying and on glycemic and hormonal responses. Annals of Nutrition and Metabolism. 1996;40(2):109–115. doi: 10.1159/000177903. [PubMed] [CrossRef] []
33. Vander Wal J. S., Marth J. M., Khosla P., Jen K.-L. C., Dhurandhar N. V. Short-term effect