Wednesday, June 3, 2020

Remdesivir 5-Day Regimen Beneficial Inbox x

Prescription Patterns Examined During COVID-19 Pandemic
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Tue, Jun 2, 3:01 AM (1 day ago)


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Ticagrelor OK'd to Reduce First MI, Stroke Risk; Remdesivir 5-Day Regimen Beneficial

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Free CME/CE Virtual Conference - St. Louis 6/20/20 - Emerging Challenges in Primary Care

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Gregg Sherman, MD, NACE Chief Medical Officer info@naceonlinemail.com Unsubscribe

3:48 AM (8 hours ago)


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Join us from the Comfort of your Home or Office!
In response to the COVID-19 pandemic, NACE has decided to bring you our Emerging Challenges live, regional events virtually this spring.
 
 
St. Louis Area Clinicians
Join us Online!
Saturday, June 20, 2020
8:30 am Central
Earn FREE CME/CE Credits
5.25 AMA PRA Category 1 CreditsTM
AAFP Credit Pending
4.25 AANP Contact Hours, which includes pharmacology hours
1.0 ANCC Contact Hour
 
CME/CE Topics:
 
  • Statin Intolerance and Cardiovascular Risk – Strategies for Improving Outcome
  • Do the Right Thing for the Right Patient: Individualizing OAB Care
  • COVID-19 Update
  • RELIEF: The Changing Landscape of Axial Spondyloarthritis: Current and Emerging Agents for Individualized Treatment
  • Optimizing Outcomes in Diabetes With GLP-1 Therapy: Case Based Strategies for Long-Term Patient Success
Join us Online!
We will recreate the onsite learning experience you are accustomed to in our virtual environment. You will have opportunities to engage with faculty and colleagues online, earn CME/CE credit, and stay up to date on the issues that matter most to you and your patients.
Register for this complimentary conference online
or call us at 1-866-266-6223.
 
NACE Accreditation Statement
The National Association for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Credit Designation Statement
The National Association for Continuing Education designates this live activity for a maximum of 4.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity
NACE AAFP Approval
*Application for CME credit has been filed with the American Academy of Family Physicians. Determination of credit is pending.
NACE AANP Approval
National Association for Continuing Education is approved as a provider of nurse practitioner continuing education by the American Association of Nurse Practitioners. AANP Provider Number 121222. This program has been approved for 4.25 Contact hour(s) of continuing education including pharmacology hours.
Med Learning Group Accreditation Statement
Med Learning Group is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. This CME activity was planned and produced in accordance with the ACCME Essentials.
Med Learning Group Credit Designation Statement
Med Learning Group designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the live activity.
Med Learning Group Nursing Credit Information
Purpose: This program would be beneficial for nurses involved in treating and managing patients with Axial Spondyloarthritis. CNE Credits: 1.0 ANCC Contact Hour.
Med Learning Group CNE Accreditation Statement
Ultimate Medical Academy/CCM is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation. Awarded 1.0 contact hour of continuing nursing education of RNs and APNs.
National Association for Continuing Education
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Tuesday, June 2, 2020


Monday, June 1, 2020

ICMR Study Says Sustained HCQ Intake Reduces Covid-19 Infection Risk Among Healthcare Workers

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ICMR Study Says Sustained HCQ Intake Reduces Covid-19 Infection Risk Among Healthcare Workers

A chemist holds a pack of hydroxychloroquine tablets in Mumbai. (AP)
A chemist holds a pack of hydroxychloroquine tablets in Mumbai. (AP)

The study highlights the potential antiviral and anti-inflammatory properties of HCQ with respect to its low cost of therapy and excellent oral bioavailability high tissue concentrations in the lungs relative to the plasma levels and acceptable safety profile.

Sneha Mordani
  • CNN-News18 New Delhi
  • Last Updated: June 1, 2020, 6:51 PM IST
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The Indian Council of Medical Research (ICMR) in a new study has underlined the importance of the use of Hydroxychloroquine for prophylaxis, or disease prevention, among health care workers, saying that the consumption of four or more maintenance doses of the anti-malarial drug was associated with a significant decline in coronavirus infection among frontline workers.
The study also says a dose-response relationship existed between the frequency of exposure to HCQ. The findings, published in the Indian Journal of Medical Research, say that the study was carried out to identify the factors associated with SARS-CoV-2 infection among the healthcare workers in the country, given the elevated risk for them.
The ICMR study further acknowledges and explains the disparity in its findings with that of with a study published in Lancet , which highlighted that HCQ did not offer therapeutic benefits to severe COVID-19 cases and was associated with increased mortality.
The Lancet study of nearly 100,000 coronavirus patients had shown no benefit in treating them with anti-viral drugs hydroxychloroquine and chloroquine and even increased the likelihood of them dying in hospital.
"This apparent disparity with the findings of the current investigation could be explained by the two different application contexts. While the observational study involving registry-analysis focussed on the treatment of hospitalised COVID-19 patients, our emphasis was on the prevention of infections among healthcare workers. In treatment settings, severe COVID-19 patients are likely to have a very high viral load and cytokine levels, which may not be improved by HCQ therapy," the study said.
"Biologically, it appears plausible that HCQ prophylaxis may inhibit the virus from gaining a foothold," the study said. In the absence of clinical trial results on safety and efficacy of HCQ chemoprophylaxis in healthcare workers, this study offers evidence of public health importance.
Interestingly, the IndianJMedRes says that while this phenomenon “cannot be fully explained by the data collected through the present study, lessons from other areas of public health could be of some help”. The parallels include seat-belt legislations vis-à-vis speeding and road traffic casualties, and promotion of use of condom with unintended effects linked to greater sexual activities, it says.
In the context of the study, the ICMR says that HCQ prophylaxis is with regards to getting infected with SARS-CoV-2 as the perceived hazard, and not adhering to conventional respiratory infection prevention measures, such as PPE use, personal hygiene and social distancing as risk-taking behaviours.
The study highlights the potential antiviral and anti-inflammatory properties of HCQ with respect to its low cost of therapy and excellent oral bio-availability high tissue concentrations in the lungs relative to the plasma levels and acceptable safety profile.
The advantage of PPE usage was also independently indicated by the multivariate model, the study says. Respondents who reported never using PPEs were also at a higher risk.

‘Hospital room of future’ aims to give Israel edge against 2nd virus wave

With robots, virtual reality glasses and early-warning systems to tell doctors if patients look headed for a sudden demise, Sheba Medical Center braces for possible new virus spike

The "hospital room of the future," built in the Israel Center for Medical Simulation at Sheba Medical Center (courtesy of Sheba Medical Center)
The 'hospital room of the future," built in the Israel Center for Medical Simulation at Sheba Medical Center (courtesy of Sheba Medical Center)
Letting robots and AI do much of the heavy lifting and keeping doctors and nurses safely away from an infectious patient with augmented reality goggles, an Israeli medical center at the forefront of the COVID-19 fight unveiled what it said was the “hospital room of the future” Tuesday.
Sheba Medical Center said it was not waiting for the future to integrate the new technologies, though, as it sought to prepare for a feared second wave of the coronavirus even as the pandemic has taken an increasingly minor role in Israeli public life.
“The technologies we’re introducing, and have brought in recently, will give us an edge in our preparedness for a second wave,” predicted Eyal Zimlichman, Sheba’s chief medical officer.
He said that his hospital, just outside Tel Aviv, was the largest recipient of coronavirus cases in Israel to date, and is “very much more prepared” for a second wave than it was for the first wave.
Zimlichman spoke to The Times of Israel after an hour-long online event on Tuesday, during which he commented on footage shot in a new room built in the Sheba-based Israel Center for Medical Simulation. The “room of the future” is a facility used for trying out new innovations used by teaching staff. It is a model for how staff hope that rooms across the campus will start to look as innovations are rolled out over the coming months.
The room includes more than a dozen technologies that were deployed in recent weeks or will be deployed soon in parts of the hospital, especially in the 450-bed coronavirus facility. Sheba has played a part in developing some of the innovations, but not all of them.
Eyal Zimlichman, chief medical officer at Sheba Medical Center in Ramat Gan (courtesy of Sheba Medical Center)
The hospital has long been working on boosting the role of technology in patient care but COVID-19 has been a major “accelerator” for digital health, said Zimlichman. He explained that the pandemic has forced staff to think creatively in order to care for the complex needs of patients while minimizing direct contact with them.
“Some of these solutions had already been tested at Sheba, but it was just COVID-19 that propelled us to push this to the front lines and get it to work,” Zimlichman said.
The webinar — titled HealthSpace 2030, because Sheba intended it to kickstart a conversation about what patent care will look like in a decade — showed footage of doctors treating an actor playing the part of hypothetical 40-year-old coronavirus patient Joel Cohen. A robot connected him for a video call with his wife, a sensor under his mattress monitored various stats, a nurse used virtual reality coaching to fix a ventilator, and artificial intelligence helped doctors catch a deterioration before it happened.
An actor in Sheba Medical Center’s “hospital room of future” uses a smart thermometer to transmit his temperature to a doctor (courtesy of Sheba Medical Center)
One feature of the new hospital room is a device that the patient operates to conduct tests based on the instructions of a doctor or nurse who talks to them via a screen. In the simulation, a doctor told the patient to attach a thermometer and other accessories to get a picture of his health.
For many conditions, doctors want technology to give early warning of deterioration, but this is particularly needed for the coronavirus, said Zimlichman. The disease can involve a sudden demise, and doctors are desperate to receive early warnings. “It has been critical for us to be able to monitor patients and see a few hours in advance when they are going to deteriorate,” he explained.
Doctors at Sheba already place sensors under mattresses in some wards to track heart-rate, respiratory rate and movement, artificial intelligence processes the data, and alerts doctors if patients look likely to take a turn for the worse. “It typically gives us a signal four to six hours before a deterioration,” said Zimlichman, adding that this is valuable time in the case of coronavirus patients.
Another alert system, still in development by Sheba and a private sector partner, is an app that monitors a patient’s voice when they talk on their cell phone. It can pick up changes in voice – or breathing – that can indicate a deterioration is likely, and alert the medical team if this is detected.
A nurse wearing protective gear and a pair of Microsoft HoloLens 2 glasses uses augmented reality functionality to perform maintenance tasks in Sheba Medical Center’s “hospital room of the future” (courtesy of Sheba Medical Center)
With technology comes the risk of technical problems, so the new patient room includes a function that allows tech support teams for the various devices to help doctors and nurses fix glitches by giving demonstrations using augmented reality. They wear Microsoft HoloLens 2  “mixed reality smart glasses.”
Zimlichman said that augmented reality has been in use throughout the pandemic and has proved helpful, as it is challenging to kit technicians in protective gear to carry out maintenance activities on virus wards.
Amitai Ziv, director of the Israel Center for Medical Simulation, said he was particularly pleased to see defense companies getting involved in healthcare. “We’re very very privileged by the fact that we found ourselves, so to speak, shifting the killing industry into the healing industry,” he said.
“Killing is not a nice word, defense is better, but a lot of those startups that we have seen, and more solid companies that are out there in the field of defense… moved and found themselves in the field of healing, and that’s something that made us all very proud.”
Patent application filed for innovation

Masks may become self-cleaning, with Israeli scientist’s USB-powered hack

Yair Ein-Eli says that by making disposable masks reusable, he’ll help solve international shortages, boost hygiene and protect the environment

Two masks that have been modified by Yair Ein-Eli to make them self-cleaning (courtesy of The Technion - Israel Institute of Technology)
Two masks that have been modified by Yair Ein-Eli to make them self-cleaning (courtesy of The Technion - Israel Institute of Technology)
An Israeli scientist has invented technology that aims to make face masks clean themselves using power from a phone charger.
Yair Ein-Eli has applied for a US patent for his innovation, which he says will boost hygiene and mitigate mask shortages. A poll just conducted by the Washington Post found that some 66 percent of American health workers surveyed said their workplaces face shortages of the masks that are most suitable for protection from the coronavirus.
“Our idea could change masks from disposable items into gadgets that people clean, meaning they wouldn’t need replacing so regularly and hospitals wouldn’t need such large supplies,” said Ein-Eli, dean of the faculty of materials science and engineering at the Technion – Israel Institute for Technology. He estimated that his cleaning mechanism can be added at around 90 cents (3 shekels) per mask.
The self-cleaning masks will look like regular face coverings, apart from an input for a USB cable. This is to power the heating element inside the mask, which gets it hot enough to kill germs. This is the only modification needed to regular masks to make them self-cleaning, Ein-Eli said.
Infra-red heat map of masks. The hot areas (yellow and red) indicate that the carbon fibers provide complete coverage. (courtesy of the Technion – Israel Institute of Technology)
“We have inserted a heating element of carbon fibers, and connected it to a USB input like one used to charge cellphone,” Ein-Eli told The Times of Israel. “The element can heat the mask to 65 to 70 degrees Celsius (149°-158° Fahrenheit), and it heats anything absorbed in the layers of the mask.”
He said that a 15- to 30-minute heating cycle would be enough to clean a mask. “If you are in your car and take your mask off, you can simply connect it to your cigarette lighter charger, and then put it back on as if it’s a new mask,” said Ein-Eli.
Yair Ein-Eli, dean of the faculty of materials science and engineering at the Technion – Israel Institute for Technology (courtesy of the Technion – Israel Institute for Technology)
He is hoping to license the technology to companies that will introduce it to their designs, initially for masks of the N95 grade and higher, which are intended for health professionals. “We’re aiming initially at medical staff who need masks and need to know that they are well-cleaned and working and functioning,” he said, adding that he then envisages it being marketed to the general public.
Ein-Eli got interested in masks by accident, in March. “I received a shipment via UPS, and asked the delivery man why he’s wearing a mask,” he recalled. “Then I asked how long he’s been wearing it for, and he said four days. I could see it had been used lots — it was really dirty, and that’s clearly a problem.”
An expert on battery technology, Ein-Eli initially wanted to add a battery to masks to enable them to self-clean. “I develop materials for batteries, and thought that perhaps I can insert a battery to masks in order to generate heat to clean the mask,” he said. “But I realized it would become very heavy and regulations wouldn’t allow it.”
Then, he hit on the idea of a charger. While it would have been simple to develop the tech for a custom charger, as he could have selected any wattage, he wanted the mask to be convenient, which meant it needed to be compatible with any phone charger.
Ein-Eli said: “It was very difficult to find the right carbon fiber that would reach the temperature at this power output at the 10 watts of a USB charger. We have 40 carbon fibers in our lab, and I spent four days looking through them, and still didn’t find one.”
But then he identified the right material, and is now hoping that his patent application will be approved. He said: “I’m expecting that this won’t only help hospitals that are trying to source protective equipment, but also the environment, by stopping many masks from being thrown away.”