A type of fasting diet may reprogramme pancreas cells, promote
the growth of new insulin-producing pancreatic cells and reduce symptoms
of Type 1 and Type 2 diabetes, a study has showed.
In the study,
led by researchers from the University of Southern California, mice were
placed on fasting mimicking diet (FMD) for four days each week
which
showed remarkable reversal of diabetes.
The mice regained healthy
insulin production, reduced insulin resistance and demonstrated more
stable levels of blood glucose -- even in the later stages of the
disease, the researchers said in the paper published in the journal
Cell.
The genes normally active in the developing pancreas of
embryonic/foetal mice are reactivated in diabetic adult mice when
cycling FMD with normal diets.
This
increases production of the protein neurogenin-3 (Ngn3) and, as a
result, promotes the creation of new, healthy insulin-producing beta
cells.
Researchers also examined pancreatic cell
cultures from human donors and found that, in cells from Type 1 diabetes
patients, nutrients mimicking fasting also increased expression of the
Ngn3 protein and insulin production.
“These
findings warrant a larger FDA trial on the use of the Fasting Mimicking
Diet to treat diabetes patients,” said Valter Longo from the University
of Southern California.
“People with diabetes could one day be
treated with an FDA-approved Fasting Mimicking Diet for a few days each
month, eat a normal diet for the rest of the month, and see positive
results in their ability to control their blood sugar by producing
normal levels of insulin and improving insulin function,” Longo added.
The most commonly-observed fast, Ekadashi,
is respected approximately twice a month, on the eleventh day of each
ascending and descending moon. During the
months of July and August, many Hindus adopt a
vegetarian diet and fast on Mondays and Saturdays until the evening.
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